Title of article
Synthesis of gem-difluoro-avermectin derivatives: Potent anthelmintic and anticonvulsant agents
Author/Authors
Peter T. Meinke، نويسنده , , Wesley L. Shoop، نويسنده , , Bruce F. Michael، نويسنده , , Timothy A. Blizzard، نويسنده , , Gerard R. Dawson، نويسنده , , Michael H. Fisher، نويسنده , , Helmut Mrozik، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
3643
To page
3646
Abstract
A series of gem-difluoro-avermectin derivatives was synthesized from the corresponding ketones at positions 4″, 4′, 13, and 23 using diethylaminosulfur trifluoride (DAST). These fluorinated avermectins exhibit potent antiparasitic activity in a new Haemonchus contortus larval assay and are equipotent to ivermectin. In addition, 23-gem-difluoro-ivermectin displays useful anticonvulsant activity in mouse models.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789871
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