Author/Authors :
Nobuhide Kawasaki، نويسنده , , Hideki Miyataka، نويسنده , , Hitoshi Matsumoto، نويسنده , , Naomi Yamashita، نويسنده , , Tsuyoshi Sakane، نويسنده , , Yutaka Mizushima، نويسنده , , Toshio Satoh، نويسنده ,
Abstract :
The antiallergic action of a series of novel mono-O-substituted trimethylhydroquinones was investigated. Among this series of the compounds, 4-[4-[4-(diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6-trimethylphenol (compound 3) showed a potent antihistaminic action (pA2=7.11) and an antiasthmatic action (100 mg/kg p. o.) on sensitized guinea pigs. Moreover, this compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized mice (100 mg/kg p. o.).
