Author/Authors :
Natalia de la Figuera، نويسنده , , Mercedes Mart?n-Mart?nez، نويسنده , , Rosario Herranz، نويسنده , , M. Teresa Garc?a-L?pez، نويسنده , , Miriam Latorre، نويسنده , , Edurne Cenarruzabeitia، نويسنده , , Joaqu?n del R?o، نويسنده , , Rosario Gonz?lez-Mu?iz، نويسنده ,
Abstract :
Conformationally constrained dipeptoid analogues containing the type II′ β-turn mimic (2S,5S,11bR)-2-amino-3-oxohexahydroindolizino[8,7-b]indole-5-carboxylate framework in place of the α-MeTrp residue, show high binding affinity and selectivity for CCK-A receptors, suggesting that a turn-like conformation could contribute to the bioactive conformation at this CCK receptor subtype.
