Title of article
Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti
Author/Authors
Anne Cosquer، نويسنده , , Vianney Pichereau، نويسنده , , Didier Le Mée، نويسنده , , Myriam Le Roch، نويسنده , , Jacques Renault، نويسنده , , Bertrand Carboni، نويسنده , , Philippe Uriac، نويسنده , , Théophile Bernard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
49
To page
54
Abstract
Seven analogues of the bacterial osmoprotectant glycine betaine (GB, trimethylammonioacetate), in which the methyl groups of the Me3N+ moiety are replaced by various substituents, were obtained by SPOS using Wang resin. Their biological activities (osmoprotection vs toxicity), appeared closely related to their uptake efficiency and their catabolism in the betaine-demethylating model bacterium Sinorhizobium meliloti.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789891
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