Title of article
N-Phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: In vivo active AMPA and NMDA(glycine) antagonists
Author/Authors
Yves P. Auberson، نويسنده , , Pierre Acklin، نويسنده , , Serge Bischoff، نويسنده , , Robert Moretti، نويسنده , , Silvio Ofner، نويسنده , , Markus Schmutz، نويسنده , , Siem J. Veenstra، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
249
To page
254
Abstract
N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine-binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsant effects in the electroshock-induced convulsion assay in mice.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789932
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