Author/Authors :
Meng-Hsin Chen، نويسنده , , Mark G. Steiner، نويسنده , , Stephen E. de Laszlo، نويسنده , , Arthur A. Patchett، نويسنده , , Matt S. Anderson، نويسنده , , Sheryl A. Hyland، نويسنده , , H. Russell Onishi، نويسنده , , Lynn L. Silyer، نويسنده , , Christian R. H. Raetz، نويسنده ,
Abstract :
A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, the enzyme responsible for the second step in lipid A biosynthesis, was identified. The most potent analog L-161,240 showed an IC50 = 30 nM in the DEACET assay and displayed an MIC of 1 3 μg/mL against wild-type E. coli.
