Title of article
Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones
Author/Authors
Richard L. Jarvest، نويسنده , , Ivan L. Pinto، نويسنده , , Stephen M. Ashman، نويسنده , , Christine E. Dabrowski، نويسنده , , Annabellee V. Fernandez، نويسنده , , L. John Jennings، نويسنده , , Patrick Lavery، نويسنده , , David G. Tew، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
443
To page
448
Abstract
Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency. Compounds 5 and 28 inhibit protease processing in HSV-2 infected cells with a selectivity index of at least 30.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789967
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