Title of article
Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism
Author/Authors
Ivan L. Pinto، نويسنده , , Richard L. Jarvest، نويسنده , , Brian Clarke، نويسنده , , Christine E. Dabrowski، نويسنده , , Ashley Fenwick، نويسنده , , Michele M Gorczyca، نويسنده , , L. John Jennings، نويسنده , , Patrick Lavery، نويسنده , , Edmund J Sternberg، نويسنده , , David G. Tew، نويسنده , , Andrew-West، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
449
To page
452
Abstract
Enedione derivatives of thieno[2,3-d]oxazinones are nanomolar inhibitors of CMV protease which act through a novel dual acylation of the catalytic serine and alkylation of the protease cysteine 161 via a Michael addition to the enedione moiety of the inhibitor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789968
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