Title of article
Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization
Author/Authors
Alexander Pasternak، نويسنده , , Yanping Pan، نويسنده , , Dominick Marino، نويسنده , , Philip E. Sanderson، نويسنده , , Ralph Mosley، نويسنده , , Susan P. Rohrer، نويسنده , , Elizabeth T. Birzin، نويسنده , , Su-Er Wu Huskey، نويسنده , , Tom Jacks، نويسنده , , Klaus D. Schleim، نويسنده , , Kang Cheng، نويسنده , , James M. Schaeffer، نويسنده , , Arthur A. Patchett، نويسنده , , Lihu Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
491
To page
496
Abstract
Backbone cyclization of urea-based somatostatin agonists resulted in novel, orally bioavailable agonists. Binding assays confirmed that the resulting conformationally constrained cyclic ureas retained the potency of their acyclic counterparts. SAR studies subsequently led to highly potent analogs, selective for receptor subtype 2, and having good oral bioavailability.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789976
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