Title of article
Allosteric modulators of the ampa receptor: Novel 6-substituted dihydrophthalazines
Author/Authors
Xue-Feng Pei، نويسنده , , Michael A. Sturgess، نويسنده , , C. Fernando Valenzuela، نويسنده , , Maria-Luisa Maccecchini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
539
To page
542
Abstract
Novel analogs of the allosteric AMPA receptor modulator SYM 2206 have been prepared. Structure/activity correlations of these novel analogs and other dihydrophthalazines (DHPs) reveal the important contribution of the heteroatom-based aryl substitutents in this class of noncompetitive inhibitors. One of the analogs (6, SYM 2189) is equipotent with the early series, but with reduced sedation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789987
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