Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands
Author/Authors :
Neil R. Curtis، نويسنده , , Janusz J. Kulagowski، نويسنده , , Paul D. Leeson، نويسنده , , Mark P. Ridgill، نويسنده , , Frances Emms، نويسنده , , Stephen B. Freedman، نويسنده , , Shil Patel، نويسنده , , Smita Patel، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
4
From page :
585
To page :
588
Abstract :
7-azaindole compounds bearing a cyclic amine moiety linked by a one or two carbon chain attached at the 2- or 3-position were synthesised and evaluated as potential dopamine D4 ligands. Highest affinity and selectivity for the D4 receptor resided in the 3-aminomethyl-7-azaindole series.
