Synthesis of bisquinolines and their in vitro ability to produce methemoglobin in canine hemolysate

Synthesis of a number of derivatives of bisquinolines (3–9) have been reported here. Effect of these compounds on in vitro methemoglobin formation and methemoglobin reductase activity has resulted in the identification of two potential compounds (5&7), showing negligible methemoglobin toxicity.