Title of article
Solid-phase synthesis of benzisothiazolones as serine protease inhibitors
Author/Authors
Kuo-Long Yu، نويسنده , , Rita Civiello، نويسنده , , Daniel G. M. Roberts، نويسنده , , Steven M. Seiler، نويسنده , , Nicholas A. Meanwell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
663
To page
666
Abstract
An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been developed. An example using this procedure for preparation of a library of human mast cell tryptase inhibitors is described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790014
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