Title of article
Cytotoxic effects of NSL-1406, a new thienopyrimidine derivative, on leukocytes and osteoclasts
Author/Authors
Jun Katada، نويسنده , , Kiyoko Iijima، نويسنده , , Michiko Muramatsu، نويسنده , , Masamichi Takami، نويسنده , , Emiko Yasuda، نويسنده , , Miki Hayashi، نويسنده , , Mari Hattori، نويسنده , , Yoshio Hayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
797
To page
802
Abstract
We synthesized a series of thienopyrimidine derivatives and examined their cytotoxic effects on several cell lines. One of the derivatives, NSL-1406, was shown to exert potent cytotoxic effects on leukemia cell line including P388 cells and J774 cells. It was also inhibitory on mouse osteoclasts and suppressed the in vitro bone resorption by osteoclasts at nanomolar concentrations.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790039
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