Title of article
Combined NK1 and NK2 tachykinin receptor antagonists: Synthesis and structure-activity relationships of novel oxazolidine analogues
Author/Authors
Takahide Nishi، نويسنده , , Tetsuya Fukazawa، نويسنده , , Koki Ishibashi، نويسنده , , Katsuyoshi Nakajima، نويسنده , , Yuki Sugioka، نويسنده , , Yukiko Iio، نويسنده , , Hitoshi Kurata، نويسنده , , Kazuhiro Itoh، نويسنده , , Osamu Mukaiyama، نويسنده , , Yumiko Satoh، نويسنده , , Takeshi Yamaguchi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
875
To page
880
Abstract
We report herein the synthesis and structure-activity relationships of a series of novel oxazolidine analogues with regards to NK1 and NK2 tachykinin receptor binding affinity. Among this series of oxazolidine analogues, some compounds exhibited excellent high binding affinities for both NK1 and NK2 receptors. In addition, we describe the inhibitory effect in vivo on SP-induced airway vascular hyperpermeability and NKA-induced bronchoconstriction in guinea pigs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790054
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