Title of article :
N-Hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase
Author/Authors :
Peter J. Connolly، نويسنده , , Steven K. Wetter، نويسنده , , Kimberly N. Beers، نويسنده , , Stephanie C. Hamel، نويسنده , , Robert H. K. Chen، نويسنده , , Michael P. Wachter، نويسنده , , Justin Ansell، نويسنده , , Monica M. Singer، نويسنده , , Michele Steber، نويسنده , , David M. Ritchie، نويسنده , , Dennis C. Argentieri، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
6
From page :
979
To page :
984
Abstract :
Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (1a and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
1999
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
790075
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=790075
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