N-(4-Bromobenzoyl)-S,S-dimethyliminosulfurane, a potent dermal penetration enhancer

N-Aroyl-, N-Arylsulfonyl-, and N-Aryl-S,S-dimethyliminosulfuranes have been synthesized and evaluated as potential dermal penetration enhancers. The title compound and Azone® exhibit similar activities for permeation of hydrocortisone through hairless mouse skin.