Title of article
Complexation study and anticellular activity enhancement by doxorubicin-cyclodextrin complexes on a multidrug-resistant adenocarcinoma cell line
Author/Authors
Anouar Al-Omar، نويسنده , , Souad Abdou، نويسنده , , Laurence De Robertis، نويسنده , , Alain Marsura، نويسنده , , Chantal Finance، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1115
To page
1120
Abstract
Ability of molecular complexes of [Doxorubicin (DX)-cyclodextrin (Cd)] to enhance the anticellular activity of antineoplasic drug Doxorubicin and to reverse its multidrug resistance has been investigated. A spectroscopic study of the α,β, and γ-[DX-Cds] complexes has been investigated in relation to their biological effects on a multidrug resistant (MDR) human rectal adenocarcinoma cell line (HRT-18). A ten fold enhancement of DX anticellular activity in presence of β-cyclodextrin alone was detected.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790102
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