Author/Authors :
Jeffery S. Carter، نويسنده , , D. J. Rogier، نويسنده , , Matthew J. Graneto، نويسنده , , Karen Seibert and، نويسنده , , Carol M. Koboldt، نويسنده , , Yan Zhang، نويسنده , , John J. Talley، نويسنده ,
Abstract :
A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.
