Author/Authors :
Jeffery S. Carter، نويسنده , , Steven Kramer، نويسنده , , John J. Talley، نويسنده , , Thomas Penning، نويسنده , , Paul Collins، نويسنده , , Matthew J. Graneto، نويسنده , , Karen Seibert and، نويسنده , , Carol M. Koboldt، نويسنده , , Jaime Masferrer، نويسنده , , Ben Zweifel، نويسنده ,
Abstract :
A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo.
