Author/Authors :
Meng-Hsin Chen، نويسنده , , Patrick P. Pollard، نويسنده , , Arthur A. Patchett، نويسنده , , Kang Cheng، نويسنده , , Liente Wei، نويسنده , , Wanda W. -S. Chan، نويسنده , , Bridget Butler، نويسنده , , Thomas M. Jacks، نويسنده , , Roy G. Smith، نويسنده ,
Abstract :
The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replaced with spirobenzodihydrothiophen derivatives to enhance not only in vitro potency but also oral activity. In this study non-aromatic D-2-amino-4-cyclohexylbutanoic analogs (8a–8d) were also identified to be active secretagogues.
