Author/Authors :
Hidefumi Suzuki، نويسنده , , Kazutoshi Shindo، نويسنده , , Akihiro Ueno، نويسنده , , Toru Miura، نويسنده , , Masao Takei، نويسنده , , Masayuki Sakakibara، نويسنده , , Hiromi Fukamachi، نويسنده , , Junichi Tanaka، نويسنده , , Tatsuo Higa، نويسنده ,
Abstract :
In the course of screening of potential leads for β2-receptor agonists, we found a novel β2-adrenoceptor selective agonist, S 1319, from a marine sponge Dysidea sp. The active compound was isolated and structurally characterized as 4-hydroxy-7-[1-(1-hydroxy-2-methylamino)ethyl]-1,3-benzothiazole-2(3H)-one, a new member of the β2-adrenoceptor agonist. This is the first example of a sponge-derived β2-adrenoceptor agonist.
