Author/Authors :
Dawei Ma، نويسنده , , Guoqiang Wang، نويسنده , , Shaomeng Wang، نويسنده , , Alan P. Kozikowski، نويسنده , , Nancy E. Lewin، نويسنده , , Peter M. Blumberg، نويسنده ,
Abstract :
Benzolactam-V7 (3a), a simplified analogues of (−)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCα.
