Title of article
Competitive inhibition of a glutamate carboxypeptidase by phosphonamidothionate derivatives of glutamic acid
Author/Authors
Chester E. Rodriguez، نويسنده , , Haiyan Lu، نويسنده , , Trang T. Ding، نويسنده , , Karyn L. Mlodnosky، نويسنده , , Azar Dastgah، نويسنده , , Vinh Q. Lam، نويسنده , , C. Blake Nichols، نويسنده , , Clifford E. Berkman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
1415
To page
1418
Abstract
Several N-thiophosphonyl-glutamates were found to be potent competitive inhibitors of a zinc-dependent glutamyl hydrolase, carboxypeptidase G (CPG). Weak inhibition exhibited by an analogous N-phosphonyl-glutamate suggests that the enhanced potency of the phosphonamidothioates is due to the presence of their sulfur ligand and its favorable interactions with active site features, presumably zinc(II).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790161
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