Title of article
Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor
Author/Authors
Huixiong Chen، نويسنده , , Bernard P. Roques، نويسنده , , Marie-Claude Fournie-Zaluski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1511
To page
1516
Abstract
A series of phosphinic compounds mimicking the transition state of substrates hydrolysed by aminopeptidase N (EC 3.4.11.2) were synthesized. These new compounds have potent inhibitory activities with Ki values in the nanomolar range. These derivatives behave as the most potent APN inhibitors designed to date.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790179
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