Title of article
Synthesis and evaluation of hapalosin and analogs as MDR-reversing agent
Author/Authors
Celeste E. OʹConnell، نويسنده , , Kathleen A. Salvato، نويسنده , , Zhaoyang Meng، نويسنده , , Bruce A. Littlefield، نويسنده , , C. Eric Schwartz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1541
To page
1546
Abstract
The marine natural product hapalosin and 22 analogs, which incorporated systematic substituent deletions or variations, were prepared. These compounds were evaluated in a cell-based assay for both MDR-reversing activity and general cytotoxicity. Some substituent modifications resulted in lower cytotoxicities, but most structural changes were either detrimental to or did not seriously alter the MDR-reversing activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790185
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