Author/Authors :
Bruce E. Maryanoff، نويسنده , , Samuel O. Nortey، نويسنده , , James J. McNally، نويسنده , , Pauline J. Sanfilippo and، نويسنده , , David F. McComsey، نويسنده , , Barry Dubinsky، نويسنده , , Richard P. Shank، نويسنده , , Allen B. Reitz، نويسنده ,
Abstract :
A variety of pyrido[1,2-a]benzimidazoles (PBIs) modified on the A-ring were prepared and evaluated for affinity to the benzodiazepine binding site on the GABA-A receptor and in animal models predictive of anxiolytic activity in humans. A-ring benzo-fused derivative 7 exhibited potent activity, as did the 6- and 7-pyrido compounds 3 and 4.
