Author/Authors :
Hiroki Sato، نويسنده , , Osamu Kitagawa، نويسنده , , Yoshiyuki Aida، نويسنده , , Jun Chikazawa، نويسنده , , Tadashi Kurimoto، نويسنده , , Mineo Takei، نويسنده , , Yoshihisa Fukuta، نويسنده , , Kiyoshi Yoshida، نويسنده ,
Abstract :
A series of arylpiperazine derivatives were prepared and evaluated for their α1-adrenoceptor antagonistic activities and 5α-reductase inhibitory activities. SAR study led to the identification of the potent dualacting compound 2f, which had a pA2 value of 7.5 for α1-adrenoceptor antagonism and an IC50 value of 1.5 nM for 5α-reductase inhibition.
