Title of article
Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine
Author/Authors
Gregory S. Basarab، نويسنده , , Douglas B. Jordan، نويسنده , , Troy C. Gehret، نويسنده , , Rand S. Schwartz، نويسنده , , Zdzislaw Wawrzak، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1613
To page
1618
Abstract
Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790199
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