Title of article
Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production
Author/Authors
George W. Muller، نويسنده , , Roger Chen، نويسنده , , Shaei-Yun Huang، نويسنده , , Laura G. Corral، نويسنده , , Lu Min Wong، نويسنده , , Rebecca T. Patterson، نويسنده , , Yuxi Chen، نويسنده , , Gilla Kaplan، نويسنده , , David I. Stirling، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1625
To page
1630
Abstract
Thalidomide, (1), is a known inhibitor of TNF-α release in LPS stimulated human PBMC. Herein we describe the TNF-α inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-α release in LPS stimulated human PBMC.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790201
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