Title of article
Picking the S1, S1′ and S2′ pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors
Author/Authors
Stephen Hanessian، نويسنده , , Samir Bouzbouz، نويسنده , , A. Boudon، نويسنده , , Gordon C. Tucker، نويسنده , , Delphine Peyroulan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1691
To page
1696
Abstract
A series of acyclic hydroxamic acids harboring strategically placed α-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790215
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