Title of article
4,10-dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists
Author/Authors
Venkatesan Aranapakam، نويسنده , , J. Donald Albright، نويسنده , , George T. Grosu، نويسنده , , Peter S. Chan، نويسنده , , Joseph Coupet، نويسنده , , Trina Saunders، نويسنده , , Xun Ru، نويسنده , , H. Mazandarani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
1733
To page
1736
Abstract
Synthesis and structure-activity relationships (SAR) of arginine vasopressin receptor (AVP) antagonists are described. Potent and orally active compounds are prepared when tricyclic 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine moiety in VPA-985 1 is replaced with a compound 7 or 12.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790222
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