Title of article :
Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors
Author/Authors :
Lijun Zhang، نويسنده , , Matthew A. Williams، نويسنده , , Dirk B. Mendel، نويسنده , , Paul A. Escarpe، نويسنده , , Xiaowu Chen، نويسنده , , Keyu Wang، نويسنده , , Bradford J. Graves، نويسنده , , Geoff Lawton، نويسنده , , Choung U. Kim، نويسنده ,
Abstract :
1,4,5,6-Tetrahydropyridazine derivative 15 and its C-5 epimer 19, which possessed side chains similar to GS4071, were synthesized via a hetero Diels-Alder reaction, and evaluated as influenza neuraminidase inhibitors. Compounds 15 and 19 exhibited a μM range of influenza neuraminidase inhibitory activity.
