Author/Authors :
Paolo Pevarello، نويسنده , , Gabriella Traquandi، نويسنده , , Alberto Bonsignori، نويسنده , , Robert A. McArthur، نويسنده , , Roberto Maj، نويسنده , , Carla Caccia، نويسنده , , Patricia Salvati، نويسنده , , Mario Varasi، نويسنده ,
Abstract :
Dextromethorphan 1 is an effective neuroprotectant in animal models of epilepsy and ischemia but showed side-effects during clinical trials limiting its potential use in a clinical setting. Here we describe the enantioselective and enantiospecific syntheses and the initial in vitro and in vivo biological evaluation of new hybrid structures between 1 and a previously disclosed α-amino amide anticonvulsant (3).
