Steroid — DNA conjugates: Improved triplex formation with 5-amido-(7-deoxycholic acid)-dU incorporated oligonucleotides

The synthesis of oligodeoxyribonucleotides incorporating 7-deoxycholic acid conjugated at C5 of dU is described. When used as third strand, these form oligonucleotide triplexes with higher stability compared to unmodified controls at physiological pH.