From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H3-receptor antagonists
Author/Authors :
Matthew J. Tozer، نويسنده , , Elaine A. Harper، نويسنده , , S. Barret Kalindjian، نويسنده , , Michael J. Pether، نويسنده , , Nigel P. Shankley، نويسنده , , Gillian F. Watt، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
6
From page :
1825
To page :
1830
Abstract :
Histamine was converted to a selective histamine H3-receptor antagonist by capping the primary amine with 2-naphthalenesulfonyl chloride. Higher receptor affinity and lower variability in the data from the various bioassays were achieved with the 2-naphthalensulfonamides of histamine homologues.
