Title of article
Synthesis and antibacterial properties of β-diketone acrylate bioisosteres of pseudomonic acid A
Author/Authors
Isobel Bennett، نويسنده , , Nigel J. P. Broom، نويسنده , , Robert Cassels، نويسنده , , John S. Elder، نويسنده , , Nicky D. Masson، نويسنده , , Peter J. OʹHanlon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1847
To page
1852
Abstract
A series of β-diketone acrylate bioisosteres 4 of pseudomonic acid A 1 have been synthesized and evaluated for their ability to inhibit bacterial isoleucyl-tRNA synthetase and act as antibacterial agents. A number of analogues have excellent antibacterial activity. Selected examples were show to afford good blood levels and to be effective in a murine infection model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790243
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