Title of article
Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid
Author/Authors
Haregewein Assefa، نويسنده , , Alison Nimrod، نويسنده , , Larry Walker، نويسنده , , Robert Sindelar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1889
To page
1894
Abstract
A number of semisynthetic analogs of oleanolic acid have been synthesized and tested for their complement inhibitory, cytotoxic and apoptotic activities. Among these, compounds 10 and 17 exhibited complement inhibitory potency superior to oleanolic acid. Both have also shown a moderate improvement in in vitro therapeutic index (T.I.).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790251
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