Title of article
Discovery of a highly potent, functionally-selective muscarinic M1 agonist,WAY-132983 using rational drug design and receptor modelling
Author/Authors
Annmarie L. Sabb، نويسنده , , G. Morris Husbands، نويسنده , , Joseph Tokolics، نويسنده , , Reinhardt P. Stein، نويسنده , , Rene P. Tasse، نويسنده , , Carl A. Boast، نويسنده , , John A. Moyer، نويسنده , , Magid Abou-Gharbia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1895
To page
1900
Abstract
Rational drug design utilizing a receptor homology model of the human muscarinic M1 receptor led to the discovery of the highly potent (Ki = 2 nM), efficacious, and in vivo functionally-selective M1 agonist, WAY-132983.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790252
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