Title of article
Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping
Author/Authors
Wayne J. Brouillette، نويسنده , , Venkatram R. Atigadda، نويسنده , , Ming Luo، نويسنده , , Gillian M. Air، نويسنده , , Yarlagadda S.Babu، نويسنده , , Shanta Bantia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1901
To page
1906
Abstract
A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3-guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evole more potent benzoic acid inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790253
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