Title of article
Isolation and structure of SCH 351633: a novel hepatitis C virus (HCV) NS3 protease inhibitor from the fungus Penicillium griseofulvum
Author/Authors
Min Chu، نويسنده , , Ronald Mierzwa، نويسنده , , Ling He، نويسنده , , Arthur King، نويسنده , , Mahesh Patel، نويسنده , , John Pichardo، نويسنده , , Andrea Hart، نويسنده , , Nancy Butkiewicz، نويسنده , , Mohindar S. Puar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
1949
To page
1952
Abstract
A new hepatitis C virus (HCV) protease inhibitor designated as Sch 351633 (1) was isolated from the fungus, Penicillium griseofulvum. Structure elucidation of 1 was accomplished by analysis of spectroscopic data, which determined compound 1 to be a bicyclic hemiketal lactone. Compound 1 exhibited inhibitory activity in the HCV protease assay with an IC50 value of 3.8 μg/mL.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790263
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