Author/Authors :
Benjamin A. Anderson، نويسنده , , Nancy K. Harn، نويسنده , , Marvin M. Hansen، نويسنده , , Allen R. Harkness، نويسنده , , David Lodge، نويسنده , , J. David Leander، نويسنده ,
Abstract :
A novel series of 3-aryl-5H-2,3-benzodiazepines with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge assay confirmed the new structures to be AMPA antagonists.
