Title of article
Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazepine ampa antagonists
Author/Authors
Benjamin A. Anderson، نويسنده , , Nancy K. Harn، نويسنده , , Marvin M. Hansen، نويسنده , , Allen R. Harkness، نويسنده , , David Lodge، نويسنده , , J. David Leander، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
1953
To page
1956
Abstract
A novel series of 3-aryl-5H-2,3-benzodiazepines with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge assay confirmed the new structures to be AMPA antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790264
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