Title of article
Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II
Author/Authors
Marc-Olivier Catrycke، نويسنده , , Raymond Houssin، نويسنده , , Jean-Pierre Hénichart، نويسنده , , Bruno Pfeiffer، نويسنده , , Pierre Renard، نويسنده , , Laurent Dassonneville، نويسنده , , Christian Bailly، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2025
To page
2030
Abstract
Indolequinone derivatives of the antitumour antibiotic BE 10988 were synthesized and evaluated for their cytotoxicity and action mechanism. The quinone system is essential to biological activity and the thiazole ring plays a major role in the poisoning of topoisomerase II.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790277
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