Title of article :
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study
Author/Authors :
Mark T. Goulet، نويسنده , , Peter J. Sinclair، نويسنده , , Frederick Wong، نويسنده , , Mary Jo Staruch، نويسنده , , Francis J. Dumont، نويسنده , , John G. Cryan، نويسنده , , Gregory J. Wiederrecht، نويسنده , , Matthew J. Wyvratt Jr.، نويسنده , , William H. Parsons، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
4
From page :
2085
To page :
2088
Abstract :
A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
1999
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
790289
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=790289
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