Author/Authors :
Christopher Fotsch، نويسنده , , G. Kumaravel، نويسنده , , Sushil K. Sharma، نويسنده , , Arthur D. Wu، نويسنده , , John S. Gounarides، نويسنده , , N. R. Nirmala، نويسنده , , Russell C. Petter، نويسنده ,
Abstract :
On-resin macrocyclization via an S Ar reaction is employed in the synthesis of tocinoic acid analogs. Specifically, an N-terminal nitrofluorobenzene is attacked by a nucleophilic C-terminal sidechain. The remaining nitro group can be reduced and acylated. NMR is used to compare the conformation of the new macrocyclic peptides to tocinoic acid.
