• Title of article

    Novel quinolinequinone antitumor agents: Structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1)

  • Author/Authors

    Tara Fryatt، نويسنده , , Dean T. Goroski، نويسنده , , Zachary D. Nilson، نويسنده , , Christopher J. Moody، نويسنده , , Howard D. Beall، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1999
  • Pages
    4
  • From page
    2195
  • To page
    2198
  • Abstract
    The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1999
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    790309