Title of article :
Novel quinolinequinone antitumor agents: Structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1)
Author/Authors :
Tara Fryatt، نويسنده , , Dean T. Goroski، نويسنده , , Zachary D. Nilson، نويسنده , , Christopher J. Moody، نويسنده , , Howard D. Beall، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Abstract :
The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
