Author/Authors :
Thomas D. Aicher، نويسنده , , Robert E. Damon، نويسنده , , Judit Koletar، نويسنده , , Christine C. Vinluan، نويسنده , , Leonard J. Brand، نويسنده , , Jiaping Gao، نويسنده , , Suraj S. Shetty، نويسنده , , Emma L. Kaplan، نويسنده , , William R. Mann، نويسنده ,
Abstract :
Several oximes of triterpenes with a 17-β hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse after a single oral dose of 100 μmol/kg. However, the mechanism of the blood glucose lowering effect is likely unrelated to PDK inhibition.
