Author/Authors :
John L. Buchanan، نويسنده , , Regine S. Bohacek، نويسنده , , George P. Luke، نويسنده , , Marcos Hatada، نويسنده , , Xiaode Lu، نويسنده , , David C. Dalgarno، نويسنده , , Surinder S. Narula، نويسنده , , Ruth Yuan، نويسنده , , Dennis A. Holt، نويسنده ,
Abstract :
The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.
