Author/Authors :
Yong Koo Kang، نويسنده , , Kye Jung Shin، نويسنده , , Kyung Ho Yoo، نويسنده , , Kyung Jae Seo، نويسنده , , Seung-Yong Park، نويسنده , , Dong Jin Kim، نويسنده , , Sang Woo Park، نويسنده ,
Abstract :
The synthesis and biological activity of the novel series of 1β-methylcarbapenems 1a-f, bearing a variety of 3″, 4″-disubstituted pyrrolidinamides as substituents at C-2, are described. Of these carbapenems, diol 1a shhowed the most potent and well balanced antibacterial activity against Gram-positive and Gram-negative. 1a was also evaluated for pharmacokinetics and in vivo therapeutic efficacy in systemic infections.
