Author/Authors :
Richard E. Armer، نويسنده , , Jacqueline S. Barlow، نويسنده , , Narinder Chopra، نويسنده , , Christopher J. Dutton، نويسنده , , David H. J. Greenway، نويسنده , , Sean D. W. Greenwood، نويسنده , , Nita Lad، نويسنده , , Jonothan Shaw، نويسنده , , Adrian P. Thompson، نويسنده , , Kam-Wah Thong، نويسنده , , Ivan Tommasini، نويسنده ,
Abstract :
Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated. Novel analogues of equal or improved efficacy in vitro and in vivo to pentaquine were discovered.
